Possible Meaning 1:
After discovering the notorious “WW” on the toilet, Hank alerts Heisenberg that he's got 3 hours to get the fuck out of his face before he launches a full-scale DEA assault. In a sudden burst of humanity, Heisenberg realizes he owes Jesse the decency of explaining they've been compromised. The picture is Walt expaining to Jesse that “we” have to leave. After a short period of total shock (pictured) Jesse devolves into a vintage Jesse sneer and counters “What do you mean, we?”
Possible Meaning 2:
Aaron Paul has just discovered that Ellie Goulding cannot perform at his wedding, and for some reason Ms. Goulding called upon Bryan Cranston to deliver the news.
Hey @elliegoulding hope your day is going beautifully. Quick question, would you like to play at my wedding? Say yes.
— Aaron Paul (@aaronpaul_8) April 18, 2013